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Doctors' Answers to "Frequently Asked Questions" - Bactrim
Answer: Not a usual problem; but, I have had one patient who experienced muscle cramps on bactrim. Try a different drug not in the sulfa family. However, many quads will experience muscle spasms, so this may have nothing to do with the Bactrim. Usually treatment with an antispasmodic will help; but, they can be really disabling.