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Doctors' Answers to "Frequently Asked Questions" - Lamictal

These comments are made for the purpose of discussion and should NOT be used as recommendations for or against therapies or other treatments. An individual patient is always advised to consult their own physician.

[posted 08/8/2000]
Question: Greetings!

Much of the medical literature regarding the medication
lamotrigine makes reference to a small number of deaths
which occurred during clinical trials, deaths which may have
been related to a lamotrigine-induced rash.

Where can I find specific information on the details of
these deaths? I have searched this site as well as PubMed,
FDA and JAMA but to no avail.

This information will help to better evaluate the risk of
death in connection with the use of lamotrigine as a mood
stabilizer for bipolar disorder.

Thank you for your assistance.

Answer: Check with the company, Glaxo, 800-334-0089

Lamictal [posted 1/12/99]
Question: Can you give me information on the drug called Lamictal?

Answer: Lamictal is an anti-seizure made by glaxo-wellcome. It is a drug unrelated to other anti seizure medications and its mode of action is unknown. It appears to have some effect on serotonin binders in the brain and is an inhibitor of foliate metabolism. There have been some unusual, but serious side effects including red cell aplasia, sudden death and rash, which have lead to hospitalization. It is a class C pregnancy drug. Usual side effects are headache, hot flashes, nausea, dizziness, somnolence and ataxia. Rhinitis is also seen on occasion, double vision, blurred vision and skin rash.

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