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Doctors' Answers to "Frequently Asked Questions" - Midrin

These comments are made for the purpose of discussion and should NOT be used as recommendations for or against therapies or other treatments. An individual patient is always advised to consult their own physician.

Midrin and bruising [posted 1/8/99]
Question: I am having spontaneous bruising. It appears to correspond with my use of Midrin. After relieving a headache with Midrin, I often notice as many as 10-12 new bruises on me with no idea how I got them. They appear on my arms and legs. Some of them on my legs look like they are from where my fingers were when I slept. I also get contact bruises where my watch is, etc. This is becoming very concerning. Is it possibly related to the Midrin or should I look elsewhere for an explanation? I am also on Zoloft.

Answer: Probably the Midrin. Stop it.

Midrin [posted 7/31/98]
Question: Is dichloralphenazone an antihistamine or a mild sedative? Or is it both? I'm very concerned because my doctor recently prescribed Midrin for both my migraines and tension headaches even though I've told him that I am severely allergic to antihistamines. Needless to say, I will not take Midrin until I can positively rule out any antihistamine connection.

Answer: Midrin is a combination of isometheptene mucate 65 mg, dichloralphenazone 100 mg and acetaminophen 325 mg. Isometheptene is a sympathomimetic amine which constricts dilated artyeriesk, dichloralphenazone is a mild sedative and acetaminophen is an analgesic.

Midrin Side Effects [posted 7/24/98]
Question: Does midrin have any side effects? If so, what are they?

Answer: Midrin is a combination pill containing isometheptene mucate 65 mg, dichloralphenazone 100 mg, and acetaminophen 325 mg. It should not be used if you have glaucoma, hypertension or a history of heart attacks. Side effects include vertigo and occasional skin rashes.

Question: I recently started taking Midrin for migraine headaches. Since beginning the Midrin I have experienced severe intestinal gas. Could this be caused by the Midrin? I also take Zoloft, Monopril, Verapamil, and Zantac.

Answer: Possibly, but the more likely cause is the calcium channel blocker, verapamil. It’s notorious for causing constipation and abdominal gas as a consequence.

Question: What is contained in the drug Midrin and what is it used for?

Answer: Midrin contains Isometheptene mucate 65 mg, dichloralphenazone 100 mg, and acetaminophen 325 mg. Isometheptene has mild sympathomimetic properties. Dichloralphenazone is a mild sedative and acetaminophen is an analgesic. Midrin is used for headaches.

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