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Doctors' Answers to "Frequently Asked Questions" - Parlodel

These comments are made for the purpose of discussion and should NOT be used as recommendations for or against therapies or other treatments. An individual patient is always advised to consult their own physician.

Parlodel Usage [posted 11/3/98]
Question: I would like to know for how long this drug should be used for fertility reasons? Your response will be highly appreciated.

Answer: Usually we use it 3-6 months, but patients with high levels or prolactin(and we try to shrink the tumor) take it for years without major problems.

Parlodel Information [posted 10/28/98]
Question: I was trying to find information on Parlodel. I took it as a fertility drug, I also had milk in both breast at that time. I was told until the milk was taken care off in my breast I could not get pregnant. So I took the drug for over 1 year, then became pregnant. Many years after that I was diagnosed with breast cancer at the age of 36, I have no family history of breast cancer and I had none of the risk factors, do you think the drug could have anything to do with the breast cancer? I have a daughter that is at high risk now and I would like to find out. Also I took the drug Benadectin for 9 months during my pregnancy when I went in for my 6 weeks check up after I had my baby there was a big poster on the wall that this drug had been recalled. My son was born with a Hyphospadias, not as bad as some I have read about, but he has had 5 surgeries due to this. He is fine today, but I would like to know why it was recalled and if you can tell me some of the side effects caused by these drugs? I would appreciate hearing from you.

Answer: I doubt that the parlodel would have any effect since it mainly works on the pituitary and has little effect on the breast. It is possible that that galactorrhea (milk) production from the pituitary had an effect, although prolactin secreting tumors are not obviously associated with an increased risk of breast cancer. As to the benadictin, genital disorders were not part of the problem. However, hypospadia is a fairly common defect in otherwise healthy males.

Odd Parlodel Side Effect [posted 10/20/98]
Question: I am 18 yrs old and I have a pituitary tumor that is causing high prolactin levels, lactation and lack of menstruation. I have been taking 2.5mg of bromocriptine (parlodel) for about 6 weeks. For the last week, I have woken up with a blinking sensation in my eyes like as if I'm opening and closing my eyes rapidly but my eyes are wide open. This lasts for about 1 minute as soon as I wake up. Please advise whether this is normal or cause for worry.

Answer: Not normal;but, hard to know the cause.

Parlodel and OTC Diet Pills [posted 10/19/98]
Question: I am taking 2.5 mg parlodel daily to treat a pituitary prolactinoma. I am trying to lose weight, since I gained a lot with this condition. Is it safe to take over the counter (OTC) diet pills, like dexatrim, with parlodel?

Answer: Probably not a problem.

Parlodel [posted 8/7/98]
Question: My wife has been taking parlodel for about six months, but not on a routine basis because of the side effects, such as dizziness, nausea and headaches. Could this drug lead to a incorrect pregnancy result?

Answer: No.

Parlodel [posted 7/31/98]
Question: My wife has been taking parlodel for about six months, but not on a routine basis because of the side effects such as dizziness, nausea and headaches. Could this drug lead to a incorrect pregnancy result?

Answer: To date all I have is indirect information from the drug reps, due to be released in March or April and I'll have more information then.

Parlodel and Prolactin levels
Question: I was taking Parlodel for about one year due to high prolactin levels causing me to skip several menstrual periods. I stopped taking the drug when I found I was 8 weeks pregnant. I am currently 2 1/2 weeks post partum and am having trouble producing enough breast milk to sustain my baby. Is there any long-term effect of Parlodel that would continue to keep my prolactin levels low? Is there some other cause I should look for?

Answer: First, what did your pituitary look like? That is, did you have a measurable tumor, or not. Second, after the parlodel did it induce any change in size in the pituitary? The parlodel itself will have no long term effect. However, it could shrink an adenoma in the pituitary. Something is right in your pituitary or you wouldn't have gotten pregnant. You might get x-rays to see the morphology of your pituitary.

Question: What are the side effects of this drug?

Answer: Parlodel(bromocriptine mesylate) is a drug used for several indications. These include treatment of adenomas of the pituitary gland(acromegaly, amenorrhea, galactorrhea, prolactinomas, etc...). It is used to treat Parkinsonís Disease. Common side effects are nausea, headache, dizziness, fatigue, abdominal cramps, diarrhea and constipation. Each disease treated has some special side effect--so, Iíd need to know the diagnosis--but, these are the common ones.

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