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Doctors' Answers to "Frequently Asked Questions" - Permax
Permax Side Effect [posted 10/6/98]
Answer: Permax belongs to a class of drugs called dopamine receptor agonists. In general, tolerance does not develop. However, we generally don't have great drugs for RLS so if it works keep with it. Most side effects center on the nervous system- anxiety, hallucinations, dyskinesis, etc. It also produces headaches and difficulty with blood pressure control(usually low). Nausea and vomiting are also seen. Long term side effects do not seem to differ markedly from short term side effects.
Permax Side Effect - Nausea [posted 8/11/98]
Answer: There are a couple of different ones, but they all have the side effect of nausea. Try decreasing the dosage somewhat, usually all that works.
Permax and Peripheral Vascular Disease [posted 7/23/98]
Answer: There are many medications utilized for restless leg syndrome. Most have some toxicity and you need to be monitored for the particular toxicity of the medication while you are seeing if it affects the syndrome. RLS differs markedly from peripheral vascular disease - whether Permax is useful in either is unclear.
Side Effect Information
Answer:Permax(pergolide mesylate) is a drug used for its dopamine receptor agonist ability. It is primarily used as a drug to treat Parkinson's Disease. Although not currently listed as an indication, it is often used to treat hyperprolactinemia(an overproduction of a pituitary hormone). The most common problem is CNS problems, especially hallucinations, confusion and general nervous system complaints. Nausea and vomiting also limit this drug in some. The most bothersome is its ability to cause cardiac irregularities and low blood pressure. Several elderly patients died during drug trials;but, it is not clear whether the drug
was the cause. Long term side effects are currently unclear since the drug is fairly new.