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Doctors' Answers to "Frequently Asked Questions" - Prograf

These comments are made for the purpose of discussion and should NOT be used as recommendations for or against therapies or other treatments. An individual patient is always advised to consult their own physician.

Prograf - Long Term Effects [posted 8/6/98]
Question: I am a liver transplant patient (5 years). I would like to know the long term effects of Prograf. I take 18 mg a day.

Answer: Prograf (tacrolimus) is a drug used to suppress humoral immunity in grafted patients. It does this mainly (with current information) by impairing T cell immunity. Dose dependent diabetes mellitus has been reported in 20-30% of patients. The drug can cause neuro and renal toxicity, and this appears fairly dose dependent. As a consequence, it needs to be used with great care when used with other drugs which affect renal function (cyclosporin for example). Heart enlargement has also been reported and there is a definite increase in malignancies with patients taking this drug (as well as most immunosuppressives).

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