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Doctors' Answers to "Frequently Asked Questions" - Ticlid

These comments are made for the purpose of discussion and should NOT be used as recommendations for or against therapies or other treatments. An individual patient is always advised to consult their own physician.

[posted 08/12/1999]
Question: Will you tell me if any of the following drugs can cause an adverse interaction. My dad is taking all of these and seems to be sleepy all of the time. The drugs are
Ticlid, Cozaar, Zoloft, Clonidine, Glyburide, Lipitor, Norvasc. He has had a stroke about 2 years ago and has had a heart attack in past years but has mostly recovered. He is also curious about whether asperin can be taken along with any of these drugs.

You reply would be greatly appreciated.

Thank You

Answer: There is no obvious interaction problem. Ticlid should not be taken with aspirin since it does what aspirin does plus.

Ticlid and Angioplasty Surgery [posted 7/17/98]
Question: What is the minimum and maximum time a patient should be on ticlid after angioplasty surgery? What is the typical recovery time for a patient who has had angioplasty? Are nuasea and feeling weak typical feelings for days after angoplasti surgery?

Answer: Usually one is on Ticlid post coronary procedure (angioplasty or stent) for about four weeks. This is to allow the body time to grow a layer of epithelia (like internal skin) over the damaged area. However, Ticlid can and is given long term to patients at high risk of stroke/embolus due to its better abilities than aspirin in affecting platelet aggregation/activation. The nausea and feeling weak are unusual in angioplasty and probably due to the drug.

Side Effects
Question: What are the side effects of Ticlid?

Answer: Ticlid is a drug used to thin blood or prevent strokes or clotting. It does this by inhibiting platelet aggregation and inhibiting platelet release of granules which produce the clotting process. Side effects are a decrease in white cell count, elevated liver enzymes, diarrhea, nausea and rash. There are other minor effects. This drug needs to have regular checks of white cell counts as well as liver functions. It should not be used in patients with liver disease, preexisting low white cell counts or patients with problems with ulcers.

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