Lopid - Possible Allergic Reaction [posted 8/14/98]
Question: My husband, age 53, was taken off hydrochlorothiazide in September. His cholesterol and triglycerides were very good and his blood pressure (for which he took Catapres) was very good. The internist also took him off Lopid. However, after he experienced stomach problems, the doctor said he should taper off the Lopid. Very soon after this, he broke out in a terrible skin condition, which 2 dermatologists were certain was psoriasis. After 3 months of agony, pain, suffering, we went to a third dermatologist who was very certain it was not psoriasis, but possibly a drug reaction/allergy most likely to being taken off the hydrodriurel. A biopsy confirmed he did not have psoriasis. The doctor has put him on prednisone for 2 weeks, then taper down, with hopes this will heal him. His body is a mess - his head/face/ears/neck are all red. The rest of his body (almost entire body) is also red/splotchy. If anyone has ever heard of any type of allergic reaction from any of these medications, we would appreciate their input.

Answer: Haven't seen this problem - I'd check with the company for this since it is clearly unusual. Parke-Davis: 800-223-0432.

Lopid side effects
Question: I have been on Lopid for cholesterol management for about 12 years and I am 50 years old. What are the long term the side affects of this drug? Are impotency and/or gas known to be some of the side affects?

Answer: Lopid (gemfibrozil) is one of several drugs used to lower cholesterol. It is very effective in moderate elevations of cholesterol and also lowers triglycerides. It was extensively studied in Finland and clearly lowers the risk of heart attack and stroke. Side effects are several. Initially, the limiting factor in most patients is gas and abdominal complaints. This will persist as long as the drug is taken. Long term, liver, kidney and bone marrow toxicity have been reported, although are uncommon. Monitoring of blood counts, liver and kidney function should be done regularly and the drug discontinued with changes in any of these organ systems.

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