Neurofibromatosis and Genetics
Question: I have that I have been told was due to a spontaneous mutation. I am the only one in my family who has this disorder. If it is in fact due to a mutation, can I still pass it on if I have children?

Answer: There are several types of inherited neuofibromatois syndromes. Sometimes the expression is subtle and members of your family might have subtle indications without the major manifestations. Chromosome 3, 9, 16, 17 and 22 have all been implicated in different types of NFM. They are called NF1, NF2f, TS and VH-L. Most are autosomal dominant, meaning you have expression of the problem if you get one, so 50% of your siblings or first cousins may be symptomatic. Consult a genetic specialist for further diagnosis if you are interested.
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